Reference of 1320266-90-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1320266-90-7, name is 8-Chloro-3-isopropylimidazo[1,5-a]pyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
Intermediate J (33 mg, 0.17 mmol) dissolved in 0.18 mL of DMF was added to NIS (39 mg, 0.17 mmol) dissolved in 0.6 mL of DMF. The reaction mixture was heated to 60 C for 3 h and then cooled to room temperature. The reaction mixture was partitioned between 1 M a2S03 and dichloromethane. The aqueous layer was then extracted with dichloromethane (3X). The organic layers were combined, dried over a2S04 and concentrated in vacuo to afford 34 mg (62% yield) of pure Intermediate K. .H-NMR (300 MHz, CDC13) delta 1.41 (d, 6H, / = 6.9 Hz), 3.20-3.31 (m, 1H), 7.28 (d, 1H, J= 5.1 Hz), 7.65 (d, 1H, J = 5.1 Hz). MS (ESI) (M+H)+ 322.1.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 8-Chloro-3-isopropylimidazo[1,5-a]pyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; UNIVERSITY OF WASHINGTON; VAN VOORHIS, Wesley, C.; HOL, Wilhelmus, G.J.; LARSON, Eric, T.; MALY, Dustin, James; MERRITT, Ethan; OJO, Kayode, K.; WO2011/94628; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem