Application of 56423-63-3, A common heterocyclic compound, 56423-63-3, name is 2-Bromopyrazine, molecular formula is C4H3BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The above oily liquid was dissolved in 10 mL of ethylene glycol dimethyl ether and 2 mL of water, and 2-bromopyrazine (129 mg, 0.81 mmol), Pd(PPh3)4 (24 mg, 0.020 mmol) and Na2CO3 (215 mg, 2.03 mmol) were stirred at 100 C for 2 hours under nitrogen atmosphere. After cooling to room temperature, the reaction solution was poured into 60 mL of water and extracted three times with 20 mL of ethyl acetate. The combined ethyl acetate was washed with brine and dried over anhydrous sodium sulfate. Filtered, and concentrated by column chromatography (petroleum ether / ethyl acetate 1/1) to give 36mg as a white solid powder that is Compound A-2.
The synthetic route of 56423-63-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shenzhen Tajirui Bio-pharmaceutical Co., Ltd.; Wang Yihan; Zhao Jiuyang; (35 pag.)CN109651359; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem