Application of 1458-01-1, These common heterocyclic compound, 1458-01-1, name is Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A stirred suspension of S^-diamino-?-chloro-pyrazine^-carboxylic acid methyl ester (1 10 g, 542.9 mmol) in MeOH (500 ml.) at 5-100C (ice-bath) is treated dropwise with a suspension of lithium hydroxide (46.6 g, 11 11 mmol) in water (500 ml_). The reaction mixture is heated to 500C for 5 hours then cooled to room temperature and stirred overnight. The resulting precipitate is collected by filtration and dried in a vacuum oven to afford the title compound as the lithium salt (di-hydrate). [M-Li]” 187
The synthetic route of 1458-01-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; WO2008/135557; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem