Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4858-85-9, name is 2,3-Dichloropyrazine, A new synthetic method of this compound is introduced below., name: 2,3-Dichloropyrazine
A suspension of 2,3-dichloropyrazine (3.5 g, 0.023 mol) in 25 % aqueous ammonia (20 mL) and THF (20 mL) was heated at 100C for 18 h in a steel bomb. The reaction was cooled to ambient temperature and the resulting crude material was evaporated to minimum. The residual material was triturated with water (15 mL), filtered and dried to afford 2-amino-3-chloropyrazine as a buff- coloured crystalline solid (2.75 g, 90%). MS (ES+) m/z: 130. 1H NMR (400 MHz, CDCl3): delta 7.94 (d, J=2.53 Hz, 1H), 7.72 (d, J=2.53 Hz, 1H), 4.90-5.12 (br. s, 2H).
The synthetic route of 4858-85-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Surase, Yogesh B.; Samby, Kirandeep; Amale, Sagar R.; Sood, Ruchi; Purnapatre, Kedar P.; Pareek, Pawan K.; Das, Biswajit; Nanda, Kamna; Kumar, Subodh; Verma, Ashwani K.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 15; (2017); p. 3454 – 3459;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem