Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13924-95-3, name is Methyl 5-hydroxypyrazine-2-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 13924-95-3
To a solution of methyl 5-hydroxypyrazine-2-carboxylate (9.25 g, 60.0 mmol) in /V,/V-dimethylformamide (120 mL) were added potassium carbonate (24.8 g, 179 mmol) and sodium chloro(difluoro)acetate (18.3 g, 120 mmol). The mixture was heated to 100 C for 15 minutes, whereupon it was filtered, and the filter cake was washed with ethyl acetate (2 x 50 mL). The combined filtrates were poured into saturated aqueous ammonium chloride solution (200 mL) and extracted with ethyl acetate (3 x 200 mL); the combined organic layers were washed sequentially with saturated aqueous sodium bicarbonate solution (2 x 300 mL) and with saturated aqueous sodium chloride solution (2 x 300 mL), dried, filtered, and concentrated in vacuo. Chromatography on silica gel (Gradient: 0% to 15% ethyl acetate in petroleum ether) afforded the product as a yellow solid. Yield: 1 .7 g, 8.3 mmol, 14%. 1 H NMR (400 MHz, CDCI3) delta 8.92 (d, J=1 .2 Hz, 1 H), 8.47 (d, J=1 .2 Hz, 1 H), 7.49 (t, JHF=71 .3 HZ, 1 H), 4.04 (s, 3H).
According to the analysis of related databases, 13924-95-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PFIZER INC.; BRODNEY, Michael Aaron; BECK, Elizabeth Mary; BUTLER, Christopher Ryan; ZHANG, Lei; O’NEILL, Brian Thomas; BARREIRO, Gabriela; LACHAPELLE, Erik Alphie; ROGERS, Bruce Nelsen; WO2015/155626; (2015); A1;,
Pyrazine – Wikipedia,
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