Synthetic Route of 5521-55-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5521-55-1 name is 5-Methylpyrazine-2-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: To a solution of R1COOH (1mmol) in DMF (5ml), DIEA (3mmol), intermediate 3 (1.1mmol) and HBTU (1mmol) were added at room temperature for 10h. The mixture was diluted with 20ml water and extracted with ethyl acetate (3×20ml). The combined organic layers were washed with saturated aqueous sodium bicarbonate and brine, and then dried over anhydrous sodium sulfate. After removing the solvent under reduced pressure, the crude product was purified by flash chromatography on silica gel, eluting with dichloromethane/methanol (2-5%), yield 70-95%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Methylpyrazine-2-carboxylic acid, and friends who are interested can also refer to it.
Reference:
Article; Yao, Dahong; Zhou, Yuxin; Zhu, Lingjuan; Ouyang, Liang; Zhang, Jin; Jiang, Yingnan; Zhao, Yuqian; Sun, Dejuan; Yang, Shilin; Yu, Yang; Wang, Jinhui; European Journal of Medicinal Chemistry; vol. 140; (2017); p. 155 – 171;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem