Some common heterocyclic compound, 5049-61-6, name is Pyrazin-2-amine, molecular formula is C4H5N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 5049-61-6
To a solution of pyrazin-2-amine (30 g, 0.32 mmol) in DCM (900 mL) at 0 C was added NBS (56 g, 0.32 mmol). The reaction mixture was stirred at ambient temperature for 3 h and then washed with sat. NaHCO3 and brine. The organic layer was dried over anhydrous Na2504, filtered and concentrated to afford 5 -bromopyrazin-2-amine (38 g, 70 %) as a white solid whichwas used directly in the next step.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5049-61-6, its application will become more common.
Reference:
Patent; PRINCIPIA BIOPHARMA INC.; BRAMELD, Kenneth A.; VERNER, Erik; WO2014/182829; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem