In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 32111-21-0 as follows. HPLC of Formula: C4H3IN2
Example 42; Synthesis of Compound 76; Compound a from the synthesis of compound 74 (255 mg) was placed in an oven dried microwave reaction vial with CuI (53.3 mg) and K3PO4 (233.4 mg) and purged with N2. To this mixture was added iodopyrazine b and the vial purged again with N2 followed by addition of 1,2-cyclohexanediamine (62.8 mg) in 2.6 ml dioxane and N2 was bubbled into the solution for 10 min and the vial crimped. The reaction vial was placed in the microwave for 30 min. at 140 C. The reaction went to half completion and was worked up by filtering off the non-product solids, concentrating under vacuum, and purifying by flash to give 139 mg compound c (47% yield). Compound c was dissolved in 3 ml 1.0 M TBAF in THF and heated to 60 C. overnight. The reaction was completed by LCMS and was diluted with H2O, extracted with EtOAc, washed with brine, dried over MgSO4, concentrated under vacuum and purified by SFC to give the final compound 76.
According to the analysis of related databases, 32111-21-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Rawson, Thomas E.; Safina, Brian; Dotson, Jennafer; Zhou, Aihe; Aliagas-Martin, Ignacio; Halladay, Jason; Liang, Jun; Rueth, Matthias; Zhu, Bing-Yan; US2007/37791; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem