Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 59489-32-6, name is 5-Chloro-2,3-dimethylpyrazine, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 5-Chloro-2,3-dimethylpyrazine
To a degassed solution of 1,1-dimethylethyl (lR,4S,6R)-4-[(E/Z)-2-(4,4,5,5-tetramethyl- l,3,2-dioxaborolan-2-yl)ethenyl]-3-azabicyclo[4.1.0]heptane-3-carboxylate D6 (150 mg) and 5-chloro-2,3-dimethylpyrazine D56 (73.5 mg) in 1,2- DME (3 ml) sodium carbonate 2M (1 ml, 2.000 mmol), dichloropalladium – triphenylphosphane (1 :2) (30.1 mg, 0.043 mmol) was added and the mixture was heated to 90C for 1.5 hours. The mixture was cooled down to room temperature, then diluted with EtOAc and washed with water and brine. Organic phase was dried over Na2S04, filtered and concentrated under reduced pressure. Crude was purified by flash chromatography on silica gel (Cy to Cy/EtOAc 1 : 1) affording the title compound D57 (26.6 mg).UPLC (IPQC): rt = 1.18 minutes peak observed: 330 (M+l) Ci9H27N302 requires 329.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 59489-32-6.
Reference:
Patent; GLAXO GROUP LIMITED; DI FABIO, Romano; WO2012/89607; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem