Reference of 4949-13-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4949-13-7, name is 2-Fluoropyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
Step A: Ethyl 3(2,4-difluorophenyl)-1-(pyrazin-2-yl)-1H-thieno[2,3-c]pyrazole-5-carboxylate Ethyl 3-(2,4-difluorophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxylate (82.0 mg, 0.266 mmol), 2-fluoropyrazine (134.6 mg, 1.372 mmol) and cesium carbonate (263.7 mg, 0.809 mmol) were dissolved in N,N-dimethylformamide (2.60 mL) at 25 C under Ar. The reaction mixture was heated to 80 C allowed to stir for 2 h. The reaction was stopped, cooled to room temperature, quenched by addition of saturated aqueous ammonium chloride (10 mL), and the mixture extracted with ethyl acetate (3 x 15 mL). The combined organic phases were washed with saturated aqueous ammonium chloride (2 x 10 mL) and saturated aqueous sodium chloride (1 x 10 mL), dried (sodium sulfate), filtered, and the solvent evaporated under reduced pressure. The crude product was purified by flash chromatography (RediSep SiO2, 40 g column) on a CombiFlash Rf purification system eluting with ethyl acetate-hexanes (0-50%). The title compound (55.3 mg, 0.143 mmol, 53.8 % yield) was recovered as a light yellow/white solid. LC-MS [M+1] = 387.3.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Fluoropyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Merck Sharp & Dohme Corp.; BURGEY, Christopher, S.; CROWLEY, Brendan, M.; DENG, Zhengwu, J.; PAONE, Daniel, V.; POTTEIGER, Craig, M.; (109 pag.)EP2411001; (2018); B1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem