In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 23688-89-3 as follows. name: 6-Chloropyrazine-2-carboxylic acid
The preparation method is:0.185 g (ie 1.0 mmol) of 2-phenoxyaniline, 0.158 g (ie 1.0 mmol) of 6-chloropyrazine-2-carboxylic acid and 30 ml of dichloromethane were added to the reaction flask. Then 0.202 g (ie 2.0 mmol) of Et3N was added, followed by 0.287 mg (1.5 mmol) of EDCl, 0.20 g (ie 1.5 mmol) of HOBt,After reacting at 25 C for 2.5 hours, the reaction was completed by TLC, and the reaction was completed. The reaction solution was washed twice with water and once with saturated brine. The organic phase is dried over anhydrous sodium sulfate and de-solued to give a crude product. Recrystallization of ethanol to give a brick red solid is 6-chloro-N-(2-phenoxyphenyl)pyrazine-2-carboxamide, m.p (melting point): 138-140 C, yield: 79.0%;
According to the analysis of related databases, 23688-89-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Shanghai Kaiai Network Technology Co., Ltd.; Xu Liyong; (8 pag.)CN108892646; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem