Electric Literature of 14508-49-7, These common heterocyclic compound, 14508-49-7, name is 2-Chloropyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 2-chloropyrazine (28.6 g, 0.25 mol) and thiourea (19 g, 0.25 mol) were added into 200 mL ethanol. The mixture was refluxed for 3 h under vigorous stir in a 500 mL three-necked flask. After alcohol was removed by the evaporation, diluted sodium hydroxide solution (30 wt%, 300 g) was gradually added into the flask. The mixture was heated with reflux for another 5 h and a large amount of ammonia was released. After cooled to ambient temperature, the pH of the solution was adjusted to 6.5 by adding quantitatively diluted hydrochloric acid. Extraction was carried out with dichloromethane. Dichloromethane layerwas collected and washed with water for several times. Yellow powder was obtained through evaporation in 68% (wt) yield. The whole synthesis is illustrated in Scheme 1. The elemental analysisresult for C4HN2S in mass %: C, 35.82; H, 2.25; N, 20.89. Experiment:C, 36.13; H, 2.01; N, 20.56.
Statistics shows that 2-Chloropyrazine is playing an increasingly important role. we look forward to future research findings about 14508-49-7.
Reference:
Article; Wu, Yining; Wu, Xuepeng; Fang, Sisi; Yang, Shuai; Li, Weitao; Wang, Huan; Yu, Xiaoxi; Polyhedron; vol. 122; (2017); p. 155 – 160;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem