Reference of 113305-94-5,Some common heterocyclic compound, 113305-94-5, name is 5-Aminopyrazine-2-carbonitrile, molecular formula is C5H4N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a suspension of 5-aminopyrazine-2-carbonitrile (44.3 mg, 0.37 mmol) in THF (10 mL) was added NaH (24.4 mg, 0.61 mmol) at 0 C. The resulting mixture was stirred at ambient temperature for 1 h. A solution of compound 3 05-5 (120 mg, 0.3 lmmol) in THF (2 mL) was added and stirred at 55 C for 3.5 h. The reaction mixture was quenched with ice water and extracted with ethyl acetate. The organic layer was washed with water and brine, dried over anhydrous Na2SO4 and concentrated. The crude product was purified by column chromatography (hexanes/ethyl acetate: 3/1) to afford the title compound 306-5 as a yellow solid (110 mg, 77 % yield).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Aminopyrazine-2-carbonitrile, its application will become more common.
Reference:
Patent; PHARMAENGINE, INC.; CAI, Xiong; QIAN, Changgeng; WANG, Yanong Daniel; (98 pag.)WO2017/132928; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem