Synthetic Route of 25911-65-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25911-65-3, name is 3-Aminopyrazine-2-carbonitrile belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
EXAMPLE 4 Synthesis of 3-Amino-6-bromopyrazine-2-carbonitrile (Intermediate 3) To a solution of intermediate 2 (1.7 g, 14 mmol) in acetic acid (40 mL) at RT was added bromine (0.95 mL, 19 mmol) slowly. The resulting mixture was heated at 60 C. for 30 min and then cooled to RT. The mixture was poured into ice water and the resulting solid filtered. After thoroughly washed with water, the title compound was obtained as a yellow solid (2.3 g, 83%). 1H NMR (500 MHz, DMSO-d6): delta 8.44 (s, 1H), 7.60 (br s, 2H). MS (ES+): m/z 199 (M+H)+.
The synthetic route of 3-Aminopyrazine-2-carbonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TargeGen, Inc.; US2007/259876; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem