Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 58139-04-1, name is 2-Iodo-3-methoxypyrazine, This compound has unique chemical properties. The synthetic route is as follows., Safety of 2-Iodo-3-methoxypyrazine
Intermediate 25 (0.15 g, 0.622 mmol) was dissolved in 1,4-dioxane (6 mL). 2-Iodo-3-methoxypyrazine (0.12 g, 0.508 mmol), cesium carbonate (0.405 g, 1.244 mmol, 1,1′-bis(diphenylphosphino)ferrocene (0.052 g, 0.093 mmol) and tris(dibenzylideneacetone) dipalladium(0) (0.028 g, 0.031 mmol) were added. The reaction tube was sealed and the mixture was stirred at 160 C. for 1 hour under microwave irradiation. After cooling, the reaction mixture was diluted with DCM and filtered over dicalite. The filtrate was concentrated in vacuo. The crude product was purified by flash column chromatography (silica gel; eluent: 7 M solution of ammonia in methanol/DCM 0/100 to 5/95). The desired fractions were collected and concentrated. This crude was further purified by preparative HPLC on (Chiralpal Diacel AS 20*250 mm) Mobile phase (CO2, MeOH with 0.2% iPrNH2) to yield compound 8 (0.010 g, 5% yield).
According to the analysis of related databases, 58139-04-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Janssen Pharmaceutica NV; Gijsen, Henricus Jacobus Maria; Van Brandt, Sven Franciscus Anna; US2014/364428; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem