These common heterocyclic compound, 22047-25-2, name is Acetylpyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: Pyrazines
AIL round-bottomed flask was charged with 2-acetylpyrazine (25 g), glacial acetic acid (175 mL), and a 30 wt% solution of HBr in acetic acid (40 mL). Pyridinium tribronide (70 g) was added to the mixture all at once as a solid. The slurry was allowed to stir for 1 h at room temperature. This resulting solution was poured into diethyl ether (1.5 L) giving a yellow solid which was recovered by gravity filtration, washed with [CH3CN] (3 x 500 [RI)] and then diethyl ether (2 x 250 [ML)] to afford 34.9 g of the title compound. Physical characteristics. MS m/z 201,202.
The synthetic route of Acetylpyrazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PHARMACIA & UPJOHN COMPANY; FLECK, Bruce, Francis; WO2004/22567; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem