In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1458-01-1 as follows. Application In Synthesis of Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate
3,5-Diamino-6-chloropyrazine-2-carboxylic acid A mixture of methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (100 g; 494 mmol), methanol (1 l) and NaOH (6 mol/l in water; 240 mL; 1.44 mol) is refluxed for 3 h. The mixture is allowed to cool to r.t. and then neutralized by addition of hydrochloric acid (6 mol/l in water; approx. 240 mL). Water (200 mL) is added. The precipitate formed is filtered off with suction, washed with water and dried at 60° C. Yield: 99.6 g (107percent of theory) C5H5ClN4O2 ESI Mass spectrum: m/z=189 [M+H]+; m/z=187 [M-H]-
According to the analysis of related databases, 1458-01-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Boehringer Ingelheim International GmbH; HECKEL, Armin; Frattini, Sara; Hamprecht, Dieter; Kley, Joerg; US2013/109697; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem