Electric Literature of 36070-79-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 36070-79-8, name is 6-Chloropyrazine-2-carboxamide belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 6-chloropyrazine-2-carboxamide (75 mg, 0.47 mmol) and (2- (methylthio)benzo[djthiazol-6-yl)methanamine (50 mg, 0.24 mmol) in DMA (475 .il) was added DIEA (46 pi, 0.26 mmol) and the resulting mixture was stirred at 120 C for 2 h. The mixture was concentrated. The residue was purified via silica gel chromatography (0 – 10 % MeOH in DCM with 0.2% NH4OH) to give the title compound (43 mg, 55%) as a tan solid. MS (ES+) C,4H,3N5052 requires: 331, found: 332 [M+Hf?. ?H NMR (500 MHz, DMSO-d6)oe 8.22 (s, 1H), 8.13 (s, 1H), 8.02 (s, 1H), 7.94 – 7.89 (m, 2H), 7.80 (d, J= 8.4 Hz, 1H), 7.61 (s, 1H), 7.48 (d, J= 9.5 Hz, 1H), 4.72 (d, J 5.8 Hz, 2H), 2.78 (s, 3H)
The synthetic route of 6-Chloropyrazine-2-carboxamide has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TESARO, INC.; JONES, Philip; CZAKO, Barbara; BURKE, Jason P.; CROSS, Jason; LEONARD, Paul Graham; (208 pag.)WO2018/81276; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem