Reference of 870787-06-7,Some common heterocyclic compound, 870787-06-7, name is 3-(Trifluoromethyl)pyrazine-2-carboxylic acid, molecular formula is C6H3F3N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A compound (2 mmol) represented by the formula (2-1) was added to a 100 mL round bottom flask.EDCI (2.4 mmol), HOBt (2.4 mmol) and 10 mL of DMF were reacted at 25 C for 1 h.Then, the compound represented by formula (2-21) or formula (2-22)(2.4 mmol) was added to the above solution,Reaction at 25 C for 24 h,After removing the solvent, column chromatography gave the desired product (yield of the desired product as a one-step yield).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-(Trifluoromethyl)pyrazine-2-carboxylic acid, its application will become more common.
Reference:
Patent; Central China Normal University; Yang Guangfu; Li Hua; Xiong Li; (10 pag.)CN109666004; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem