Some common heterocyclic compound, 313339-92-3, name is 3,5-Dichloropyrazine-2-carbonitrile, molecular formula is C5HCl2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 3,5-Dichloropyrazine-2-carbonitrile
To a solution of 44 3,5-dichloropyrazine-2-carbonitrile (3) (120mg, 0.69mmol) in 45 formamide (5.3g, 120mmol) were added 46 H2SO4 (37muL, 0.69mmol), FeSO4ยท7H2O (190mg, 0.69mmol) in 47 H2O (700muL) and 48 H2O2 (230muL, 2.1mmol) in H2O (700muL) dropwise at 0C, and the mixture was stirred at the same temperature for 30min. The reaction mixture was quenched with 49 ice water and extracted with EtOAc. The aqueous layer was extracted with EtOAc. The combined organic layer was washed with water, saturated aqueous NaHCO3 and brine, dried over Na2SO4 and concentrated in vacuo to give 7 4 (99mg, 66%) as a pale yellow solid. 1H NMR (DMSO-d6) delta ppm 8.18 (1H, br s), 8.28 (1H, br s); MS (ESI) m/z 197, 199 [M-HCl+H2O]-
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 313339-92-3, its application will become more common.
Reference:
Article; Kunikawa, Shigeki; Tanaka, Akira; Takasuna, Yuji; Tasaki, Mamoru; Chida, Noboru; Bioorganic and Medicinal Chemistry; vol. 26; 20; (2018); p. 5499 – 5509;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem