Related Products of 91476-80-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 91476-80-1 name is 5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Compound 2A (126.0mg, 0.48mmol) was dissolved in 10.0ml acetonitrile, Ar gas protection. Compound 3a-1 (118.0mg, 0.96mmol), and lithium perchlorate (102.0mg, 0.96mmol), the reaction mixture was heated to 80 deg. C, the reaction after 20 hours, cooled to room temperature.The reaction mixture was evaporated to dryness and the residue with CH2Cl2Dissolved, the organic phase was washed 3 times with saturated NaCl solution, dried over anhydrous Na2SO4Dried, filtered, and evaporated to dryness and the residue was separated by column chromatography (dichloromethane: methanol = 100: 1-50: 1), to give a compound 80.8mg as a white solid, mp: 86-88 deg. C, a yield of 45.0%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine, and friends who are interested can also refer to it.
Reference:
Patent; Chinese Academy of Sciences, Shanghai Institute of Medicine; Nanjing Changao Pharmaceutical Technology co., LTD; YANG, YU SHE; CAO, XU FENG; LI, ZHAN; LI, WEI; (78 pag.)CN103965194; (2016); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem