Related Products of 313339-92-3, A common heterocyclic compound, 313339-92-3, name is 3,5-Dichloropyrazine-2-carbonitrile, molecular formula is C5HCl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Potassium tert-butoxide (0.658 g, 5.86 mmol) and tetrahydrofuran (8 ml) were mixed to give a colorless suspension. The reaction mixture was cooled to 0C and 3,3- difluorocyclobutanol (0,683 g, 6,32 mmol) diluted in tetrahydrofuran (3 ml) were added by a syringe and the reaction mixture was stirred for 30 min at 0C while the color changed to orange. Then, the reaction mixture was cooled to -78C and a solution of 3,5-dichloropyrazine-2-carbonitrile (1 g, 5.75 mmol) in tetrahydrofuran (4 ml) was added over 10 min by syringe. The cooling bath was removed and the reaction mixture was stirred for 2 h at 25C.The reaction mixture was diluted with ethyl acetate and 1M sodium hydroxide was added. The aqueous layer was extracted with ethyl acetate (3 x). The organic layer was dried over sodium sulfate and concentrated. The residue was purified by flash chromatography to give 3-chloro-5-(3,3-difluorocyclobutoxy)pyrazine-2- carbonitrile (1.11 g, 4.54 mmol). LCMS (ESI+) m/z [M+H]+: 246
The synthetic route of 313339-92-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ABBVIE DEUTSCHLAND GMBH & CO. KG; BACKFISCH, Gisela; BAKKER, Margaretha; BLAICH, Guenter; BRAJE, Wilfried; DRESCHER, Karla; ERHARD, Thomas; HAUPT, Andreas; HOFT, Carolin; KLING, Andreas; LAKICS, Viktor; MACK, Helmut; OELLIEN, Frank; PETER, Raimund; POHLKI, Frauke; RELO, Ana Lucia; (313 pag.)WO2017/50807; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem