Related Products of 243472-70-0,Some common heterocyclic compound, 243472-70-0, name is 5-Bromo-2,3-diphenylpyrazine, molecular formula is C16H11BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a mixture of 5- bromo-2,3-diphenylpyrazine (1 g, 3.21 mmol) and 4-(isopropylamino)butan-1 -ol (2.32 g, 17.7 mmol) was added potassium iodide (266 mg, 1 .6 mmol). The mixture was stirred in a pressure vessel at 140C for 2 days. The reaction mixture was cooled to room temp and diluted with water. The mixture was extracted with EtOAc (x4) and the combined organic layers washed with brine, dried over Na2S04, filtered and concentrated. The crude residue was purified with column chromatography eluting with 0-2% MeOH in DCM. The fractions of the desired product were combined, concentrated, and dried under reduced pressure to obtain a brown oil (0.82 g, 71 %). 1 H NMR (400 MHz, Chloroform-d) d 8.02 (s, 1 H), 7.49 – 7.42 (m, 2H), 7.39 – 7.33 (m, 2H), 7.29 – 7.21 (m, 6H), 4.78 (p, J = 6.7 Hz, 1 H), 3.68 (t, J = 6.4 Hz, 2H), 3.43 (dd, J = 9.2, 6.7 Hz, 2H), 1.76 (qd, J = 7.8, 7.1 , 3.9 Hz, 2H), 1.65 (q, J = (0159) 6.8 Hz, 2H), 1.28 (d, J = 6.7 Hz, 6H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Bromo-2,3-diphenylpyrazine, its application will become more common.
Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF MICHIGAN; HOLINSTAT, Michael; ADILI, Reheman; WHITE, Andrew; (43 pag.)WO2019/204447; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem