Reference of 69214-33-1,Some common heterocyclic compound, 69214-33-1, name is 8-Chloroimidazo[1,2-a]pyrazine, molecular formula is C6H4ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A slurry of Intermediate B (400 mg, 1.6 mmol), 8-chloroimidazo[l,2-a]pyrazine (272 mg, 1.77 mmol) and Hunig’s Base (0.84 ml, 4.8 mmol) in DMA (10 ml) was heated at 75 C overnight. The cooled reaction mixture was partitioned between ethyl acetate and sat. aqueous sodium bicarbonate solution. The organic layer was washed with brine (2 x 50 mL) followed by water (2 x 50 mL). The organic layer was separated, dried over sodium sulfate, filtered and concentrated to dryness. The crude oil was dissolved in minimal DCM and purified by silica gel column chromatography (0-100% ethyl acetate in hexanes, 20 min) to afford 21-1 as an oil. LRMS m/z (M+H) 366.3 found, 366.4 required.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 8-Chloroimidazo[1,2-a]pyrazine, its application will become more common.
Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; REGER, Thomas, S.; SKUDLAREK, Jason, W.; (0 pag.)WO2016/85784; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem