Reference of 59489-71-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 59489-71-3, name is 2-Amino-5-bromopyrazine, This compound has unique chemical properties. The synthetic route is as follows.
Example 54 2 (R)- (3-CHLORO-4-METHANESULFONYL-PHENYL)-3-CYCLOPENTYL-N- [5- (L (S), 2-dihydroxy- ethyl)-pyrazin-2-yl]-propionamide [000276] This compound was prepared through a linear synthesis (Method A) and a convergent synthesis (Method B). Method A: [000277] A solution of 2-amino-5-bromopyrazine (500 mg, 2.87 mmol) in N, N- dimethylformamide (15 ML) was treated with tetrakis (triphenylphosphine) palladium (0) (66 mg, 0.06 MMOL), N, N-DIISOPROPYLETHYL AMINE (1.25 mL, 7.18 mmol), lithium chloride (426 mg, 0.06 mmol), and vinyltri-n-butyltin (840 L, 2.87 mmol), and the reaction was heated at 120C for 4 h. After such time, the reaction was cooled to 25C, treated with a saturated aqueous potassium fluoride solution (10 mL), and stirred at 25C overnight for 16 h. The solution was then diluted with methylene chloride (25 ML) and extracted with methylene chloride (3 x 15 mL). The combined organic layers were dried over sodium sulfate, filtered, and concentrated in vacuo. Biotage chromatography (FLASH 40S, Silica, 40/60 to 20/80 HEXANES/ETHYL acetate) afforded 2-amino-5-vinylpyrazine (211 mg, 61%) as a light yellow solid: EI-HRMS m/e calcd for C6H7N3 (M+) 121.0640, found 121.0642.
The chemical industry reduces the impact on the environment during synthesis 2-Amino-5-bromopyrazine. I believe this compound will play a more active role in future production and life.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2004/52869; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem