Related Products of 6705-33-5,Some common heterocyclic compound, 6705-33-5, name is Pyrazin-2-ylmethanol, molecular formula is C5H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of pyrazin-2-ylmethanol (55 mg, 0.5 mmol) in THF (4 mL) was added potassium tert-butoxide (110 mg, 1.0 mmol). After stirring for 10 min, Example 27G (100 mg, 0.25 mmol) was added to the reaction mixture in portions. The mixture was stirred at ambient temperature for 2 hours, quenched with saturated aqueous NH4Cl and extracted by EtOAc (3×10 mL). The combined organic extracts were concentrated under reduced pressure. Purification by flash chromatography (silica gel, MeOH/Et3N (10:1) in CH2Cl2 in 0-30% gradient) provided 61 mg (47%) of the title compound. 1H NMR (300 MHz, DMSO-d6) delta ppm 0.34-0.49 (m, 4H), 1.08-1.24 (m, 1H), 1.33-1.44 (m, 9H), 3.90 (s, 3H), 4.15 (d, J=7.1 Hz, 2H), 5.39 (s, 2H), 6.83 (s, 1H), 7.27 (d, J=8.8 Hz, 1H), 7.60 (dd, J=8.7, 1.9 Hz, 1H), 7.77 (d, J=2.4 Hz, 1H), 8.56-8.70 (m, 2H), 8.93 (d, J=1.4 Hz, 1H); MS (DCI/NH3) m/z 488 (M+H)+
The synthetic route of 6705-33-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ABBOTT LABORATORIES; US2010/69348; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem