Reference of 914452-71-4, The chemical industry reduces the impact on the environment during synthesis 914452-71-4, name is 2-Bromo-6-methylpyrazine, I believe this compound will play a more active role in future production and life.
To a solution of 2-bromo-6-methyl-pyrazine (3.10 g, 17.92 mmol, 1.00 eq) and TRIISOPROPYL BORATE (4.04 g, 21.50 mmol, 4.93 mL, 1.20 eq) in THF (30.00 mL) was added n-BuLi (2.5 M in n-hexane, 7.88 mL, 1.10 eq) dropwise at -100 C. The mixture was stirred at -100 C for 1 hour. TLC indicated reactant 1 was consumed completely and many new spots formed. The crude product hydroxylithium;(6-methylpyrazin-2-yl)boronic acid (2.90 g, crude) in THF (30 mL) was used into the next step without further purification. 0.5 mL of the mixture was quenched by MeOH (3 mL) and confirmed by HNMR. 1H MR (400MHz, D20) 8.26 (s, 1H), 7.98 (s, 1H), 2.30 (s, 3H) 1H MR (400MHz, D20) delta = 8.26 (s, 1H), 7.98 (s, 1H), 2.30 (s, 3H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-6-methylpyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; THE GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT, INC.; KANEKO, Takushi; FOTOUHI, Nader; (68 pag.)WO2018/67762; (2018); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem