Application of 5049-61-6, A common heterocyclic compound, 5049-61-6, name is Pyrazin-2-amine, molecular formula is C4H5N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Description 4 5-Chloro-2-pyrazinamine (D4); Aminopyrazine (10 g, 105 mmol) was dissolved in dimethylformamide (60 ml) and N- chlorosuccinimide (15.36 g, 115 mmol) was added portionwise under argon at room temperature. After 5 minutes, the temperature rose from 25C to 45C (care required – exothermic reaction). An ice bath was placed underneath the reaction mixture and the mixture was stirred for 30 minutes and then allowed to warm to room temperature. The mixture was poured onto water and extracted with diethyl ether (x 5). The diethyl ether layer was evaporated under reduced pressure. The product was purified by Biotage column chromatography eluting with 10% ethyl acetate in pentane to afford the title compound (1.40 g). ¹H NMR (CDCI3) 8.02 (1 H, s), 7.76 (1 H, s), 4.61 (2H, s).
The synthetic route of 5049-61-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXO GROUP LIMITED; WO2005/123723; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem