In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 356783-16-9, name is 3,6-Dichloropyrazine-2-carbonitrile belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 3,6-Dichloropyrazine-2-carbonitrile
KF2H2O (1.3 g, 6 eq) and TBAB (tetrabutylammoniumbromide) (0.3 g, 0.4 eq) were added into the mixed solventcontaining 4 mL of DMSO and 8 mL of toluene. Thetoluene was subsequently removed by distillation underreduced pressure. A further 8 mL of toluene was thenadded and once again removed by distillation underreduced pressure with the purpose of removing the moisture of the reagent relating to the reaction. Then, 3,6-dichloropyrazine-2-carbonitrile (0.4 g, 1 eq) was addedand the mixture was stirred at 50 C for 3 h. Subsequently,anhydrous K2CO3 (0.04 g) and 30% H2O2(0.28 mL) were added into the solution at 0 C stirring for1.5 h at 25 C. Water (1 mL) and NaHCO3 (0.132 g)were added into the 3,6-difluoropyrazine-2-carboxamidewith magnetic stirring for 8 h at 50 C and TLC (MeOH:EA = 1:1, v/v, Rf = 0.72) was used to monitor thereaction. Then, 6 M HCl was added into the solution andthe pH of the solution was adjusted to 1.0. Then, thesolution was extracted with ethyl acetate (5 9 10 mL).The organic phase was washed with brine (3 9 10 mL),dried with anhydrous Na2SO4, and was filtered to removethe drying agent. The ethyl acetate was removed by distillationunder reduced pressure to obtain the crudecompound of 7. Then, the crude 7 was dissolved intoEtOH (6 mL, 95%). The suspension was heated to refluxfor 30 min and was filtered to crystallize. The filtrate wascooled to 25-30 C which was kept for 4 h. The crystal ofpure 6-fluoro-3-hyroxypyrazine-2-carboxamide (7)(0.25 g, 60%) was obtained in open system.
The synthetic route of 356783-16-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Liu, Feng-Liang; Li, Cui-Qin; Xiang, Hao-Yue; Feng, Si; Chemical Papers; vol. 71; 11; (2017); p. 2153 – 2158;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem