Related Products of 723286-80-4, The chemical industry reduces the impact on the environment during synthesis 723286-80-4, name is tert-Butyl 3-bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate, I believe this compound will play a more active role in future production and life.
The compound obtained in Step 4 (53 mg) was dissolved in chloroform (2 mL), trifluoroacetic acid (0.2 mL) was added and stirred overnight at room temperature. The oil obtained reaction solution by concentration under reduced pressure was dissolved in N, N- dimethylformamide (1.5 mL), Was stirred for 2 hours at 200 C. was added cesium carbonate (111 mg) and 4-fluoro-2- (trifluoromethyl) benzonitrile (64 mg). To the reaction solution was extracted 3 times with ethyl acetate after addition of water, The organic layer was washed with water and saturated brine, Dried and concentrated with sodium sulfate. The resulting residue to give the title compound purified by silica gel column chromatography (19mg, 30%). LRMS (ESI) m / z 372 [M + H] +.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 3-bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; TAIHO PHARMACEUTICAL COMPANY LIMITED; MINAMIGUCHI, KAZUHISA; OKAJIMA, SHIGEO; AOKI, SHINICHI; ASAI, MASANORI; ASAI, TAKAHIRO; YAMANAKA, HIROYOSHI; DOHI, SUGURU; (149 pag.)JP5851663; (2016); B1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem