Application of 122-05-4,Some common heterocyclic compound, 122-05-4, name is Pyrazine-2,5-dicarboxylic acid, molecular formula is C6H4N2O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Pyrazine-2,5-dicarboxylic acid 2 was prepared according to the procedure of Schut et al. Compound 2 was esterified with methanol and hydrogen chloride gas to give dimethyl pyrazine-2,5-dicarboxylate 3. A suspension of 3 (2.0 g, 10.19 mmol) in methanol (250 mL) was stirred as a solution of sodium hydroxide (408 mg in 10.1 mL of water) was added. The mixture was then stirred for another 16 h. The solvent was removed under reduced pressure and the resulting solid was dissolved in water and filtered. The filtrate was acidified with 1N HCl, and the precipitated product was collected by filtration and dried under vacuum to give 4, 1.36 g, 73% yield of product as a white solid.
The synthetic route of 122-05-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Agyin, Joseph K.; Santhamma, Bindu; Roy, Sudipa S.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 23; (2013); p. 6455 – 6458;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem