Related Products of 27825-20-3,Some common heterocyclic compound, 27825-20-3, name is Methyl 3-Hydroxy-2-pyrazinecarboxylate, molecular formula is C6H6N2O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(1) 308 g (2 mol, 1 eq) of methyl 3-hydroxy-2-pyrazinecarboxylate and 956 g (6 mol, 3 eq) of liquid bromine were added to 4 L of acetonitrile,The mixture was stirred at 27 C for one hour,TLC detection reaction completely,The reaction solution was poured into 4 L of water,The excess liquid bromine was removed with a saturated aqueous solution of sodium sulfite,Standing filter,Filter cake vacuum drying at room temperature,300 g of the product methyl 6-bromo-3-hydroxy-2-pyrazinecarboxylate (including its tautomer 6-bromo-3-oxo-3,4-dihydro-2-pyrazinecarboxylic acid Methyl ester),Yield 65%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 3-Hydroxy-2-pyrazinecarboxylate, its application will become more common.
Reference:
Patent; Qingdao Hangdao District Chinese Medicine Hospital; Lu, Yanmin; (5 pag.)CN105732524; (2016); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem