Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 875781-43-4, name is 2-Bromo-5H-pyrrolo[2,3-b]pyrazine, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 2-Bromo-5H-pyrrolo[2,3-b]pyrazine
To a solution of 2-bromo-5H-pyrrolo [2, 3-b] pyrazine (1.94 g, 9.8 mmol) in DMF (20 mL) was added sodium hydride (60, 525.3 mg, 13.13 mmol) in an ice bath. The mixture was stirred at this temperature for 30 min and then SEMCl (2.26 mL, 12.6 mmol) was added. The mixture was stirred at rt overnight. The reaction mixture was quenched with water (40 mL) . The resulting mixture was extracted with DCM (30 mL × 3) . The combined organic layers were dried over anhydrous Na2SO4and concentrated in vacuo. The residue was purified by silica gel column chromatography eluted with PE/EtOAc (v/v) 7/1 to give a light yellow oily product (2.40 g, 75.0) .[0819]MS (ESI, pos. ion) m/z: 328.15 [M+1]+.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 875781-43-4.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; LIU, Bing; ZHANG, Yingjun; CHENG, Changchung; HUANG, Jiuzhong; BAI, Shun; REN, Xingye; LI, Zhi; ZHOU, Youbai; (368 pag.)WO2016/615; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem