Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 486460-21-3, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C6H7F3N4
To a solution of 3-(trifluoromethyl)-5,6,7,8-tetrahydro-[ 1 ,2,4] triazolo[4,3-a]pyrazine ( 1.90 g) in DMF ( 10 mL) was added 2C03 (2.35 g) and l -bromo-3-chloropropane (1.70 mL) at rt. The reaction mixture was heated at 80 C for 3 h, diluted with water and extracted with ethyl acetate. The combined organic phases were dried over anhydrous Na2S04 for lh, and filtered. The filtrate was concentrated in vacuo and the residue was chromatographed with a silica gel column (eluting agent: 30: 1 (v/v) DCM/MeOH) to give the title compound as transparent liquid (0.68 g, 30.00 %).
According to the analysis of related databases, 486460-21-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu; WO2013/71697; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem