Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 59489-71-3, name is 2-Amino-5-bromopyrazine, A new synthetic method of this compound is introduced below., Product Details of 59489-71-3
To the stirring solution of 2 (50 g, 287 mmol) in 1, 4-dioxane (1250 mL) was added 4- methoxycarbonyl phenyl boronic acid (2a) (56.89 g, 316 mmol) followed by 1M aqueous solution of potassium carbonate (575 mL, 574 mmol) at RT and purged with N2 gas for 40 minutes. Bis(triphenylphosphine)palladium(II)chloride (14.12 g, 20.12 mmol was added to the reaction mixture. The reaction mixture was heated to reflux temperature for 4h. After completion of the reaction (Confirm by TLC) the reaction mixture was cooled to RT and filtered through a bed of celite. The bed was washed with ethyl acetate (3 X 300 mL). Organic layer was separated and aqueous layer was re extracted with ethyl acetate (2 X 400 mL). The combined organic layer was washed with water, dried over sodium sulfate and concentrated under vacuum. The crude material was purified by column chromatography over silica gel (230-400 mesh) using 3.5% of MeOH in DCM as an eluent to afford 3 (39.1 g, 57%) as yellow solid.
The synthetic route of 59489-71-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MMV MEDICINES FOR MALARIA VENTURE; UNIVERSITY OF CAPE TOWN; WATERSON, David; WITTY, Michael John; CHIBALE, Kelly; STREET, Leslie; GONZALEZ CABRERA, Diego; PAQUET, Tanya; (36 pag.)WO2017/9773; (2017); A1;,
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