Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 153800-11-4, name is 2-Ethynylpyrazine, This compound has unique chemical properties. The synthetic route is as follows., Formula: C6H4N2
Preparation 172:2-(4-Amino-3-bromo-5-pyrazin-2-ylethinyl-phenyl)-4-methyl-l,3-thiazole-5-carbo xylic acid ethyl ester; [1397] 2-(4- Amino-3-bromo-5-iodo-phenyl)-4-methyl- 1 ,3-thiazole-5-carboxylic acid ethyl ester (0.5g, lmmol) obtained in Preparation 171, dichlorobis(triphenylphosphine)palladium (37mg, 0.05mmol), cupper iodide (lOmg, 0.05mmol), 2-ethinylpyrazine (220mg, 2.0mmol) and triethylamine (4.47mL, 5mmol) were added to 5mL of tetrahydrofuran, and the mixture was reacted for 12 h at room temperature. After reaction, the solution was filtered through celite using 3OmL of ethyl acetate. After filtration, 2OmL of sodium bicarbonate solution was added, and 1OmL of ethyl acetate was added. The organic layer was separated, dried over anhydrous magnesium sulfate, filtered and purified by column chromatography to give the title compound (0.5g, Yield 52%).[1398] NMR: 1H-NMR(DMSO) delta 8.78(1H, s), 8.59(1H, s), 8.53(1H, s), 8.12(1H, s), 8.00(1H, s), 5.19(2H, s), 4.34(2H, q), 2.74(3H, s), 1.36(3H, t)[1399] Mass(EI): 444(M++ 1)
According to the analysis of related databases, 153800-11-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; LG LIFE SCIENCES LTD.; CHOI, Sung Pil; KIM, Geun Tae; SONG, Jeong Uk; KIM, Tae Hun; LIM, Dong Chul; KANG, Seung Wan; KIM, Hyung Jin; WO2010/93191; (2010); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem