Synthetic Route of 41270-66-0, These common heterocyclic compound, 41270-66-0, name is 5-Chloro-2,3-diphenylpyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a 10 liter reactor, 2 liters of isopropylamine and 222 g of SLP-3 were added and the reaction was stirred at room temperature for 48 hours until the reaction was completed.Add 5 liters of ethyl acetate and 3 liters of water to stir, and let stand for phase separation; the organic phase is washed with dilute hydrochloric acid, water and saturated sodium bicarbonate, dried over anhydrous sodium sulfate, filtered and concentrated to obtain crude product; crude product is ethyl acetate. Recrystallization from petroleum ether gave 205 g of white solid SLP-4.Yield: 85%.1H NMR (400 MHz, CDCl3): delta 7.89 (s, 1H), 7.43-7.22 (m, 10H), 4.59 (d, 1H), 4.08 (m, 1H), 1.30 (d, 6H)ESI/MS+(m/z):289
The synthetic route of 41270-66-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shanghai Aikangrui Pharmaceutical Technology Co., Ltd.; Fan Linfeng; Zhu Yangwei; Qiu Aiyun; Lv Bojie; Xu Zhonghui; Zhang Changxuan; (11 pag.)CN106316967; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem