Application of 38557-72-1, The chemical industry reduces the impact on the environment during synthesis 38557-72-1, name is 2-Chloro-3,5-dimethylpyrazine, I believe this compound will play a more active role in future production and life.
A solution of intermediate 72 (0.24 M in THF, 43 mL, 10.32 mmol) was added to a flask containing 4-bromo-2,6-dimethylpyridine (CAS: 5093-70-9, 1.75 g, 9.38 mmol) and bis(triphenylphosphine)palladium(II) dichloride (0.395 g, 0.56 mmol) under N2. Then N,N,N?,N?-tctramcthylcthylcncdiaminc (1.538 mL, 10.32 mmol) was added and the mixture was stirred at 60 C for 18 h. The mixture was quenched with the addition of a 1/1 solution of sat NH4Cl/32% aq NTb and then it was extracted with EtOAc. The organic layer was separated, dried (Na2S04), filtered and the solvents evaporated in vacuo. The crude product was purified by flash column chromatography (Si02, EtOAc in heptane 0/100 to 80/20). The desired fractions were collected and the solvents evaporated in vacuo to yield intermediate 48 (2.59 g, 955) as a yellow oil.; Intermediate 53 was prepared following an analogous procedure to the one described for the synthesis of intermediate 48 using intermediate 73 and 2-chloro-3,5- dimethylpyrazine (CAS: 38557-72-1) as starting materials.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-3,5-dimethylpyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; BARTOLOME-NEBREDA, Jose Manuel; TRABANCO-SUAREZ, Andres, Avelino; MARTINEZ-VITURRO, Carlos Manuel; DELGADO-JIMENEZ, Francisca; CONDE-CEIDE, Susana; VEGA RAMIRO, Juan, Antonio; (178 pag.)WO2019/243527; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem