Synthetic Route of 136927-64-5,Some common heterocyclic compound, 136927-64-5, name is 1-Chloropyrrolo[1,2-a]pyrazine, molecular formula is C7H5ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a mixture of a (248 mg, 1.0 mmol) and b (152 mg, 1.0 mmol) was added 2.0 mL of Hunig?s base (9.5 mmol).The resulting mixture was stirred at 130 C. for 3 h. After the mixture was cooled down to room temperature, 100 mL of isopropanol/chloroform (1:2) was added, and the mixture was then washed with saturated aqueous NaHCO3 (2×20 mL) and brine (2×50 mL). The organics were dried over MgS04 and concentrated under reduced pressure. The residue was purified via flash chromatography on silica gel (0-10% MeOH inEtOAc) to get the desired product as a brown powder (250 mg, 67%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Chloropyrrolo[1,2-a]pyrazine, its application will become more common.
Reference:
Patent; ChemoCentryx, Inc.; Fan, Junfa; Krasinski, Antoni; Lange, Christopher W.; Lui, Rebecca M.; McMahon, Jeffrey P.; Powers, Jay P.; Zeng, Yibin; Zhang, Penglie; US2014/154179; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem