Adding a certain compound to certain chemical reactions, such as: 117719-17-2, name is 5-Bromo-3-morpholinopyrazin-2-amine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 117719-17-2, Recommanded Product: 5-Bromo-3-morpholinopyrazin-2-amine
A mixture of 5-bromo-3-morpholin-4-yl-pyrazin-2-ylamine (0.3 g, 1 eq), methyl 4- oxobutanoate (182 mu, 1.5 eq), 1 , 1 ,3,3-tetramethylbutyl isocyanide (305 mu, 1 .5 eq) and ZrCL, (54 mg, 0.2 eq) in PEG-400 (3 mL) was heated at 50 C under open air for 20 h and 24 h more. On cooling, H20 (60 mL) was added and the mixture was extracted with EtOAc (3 x 50 mL). The organics were dried, filtered and evaporated and the residue was purified by automated chromatography (Biotage, eluent: 20% to 40% EtOAc in Cyclohexane) to give the expected product 1-14 (155 mg, 26% yield) as a yellow oil.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Bromo-3-morpholinopyrazin-2-amine, and friends who are interested can also refer to it.
Reference:
Patent; CENTRO NACIONAL DE INVESTIGACIONES ONC&Oacgr;LOGICAS (CNIO); PASTOR FERNANDEZ, Joaquin; MARTINEZ GONZALEZ, Sonia; ALVAREZ ESCOBAR, Rosa Maria; RODRIGUEZ ARISTEGUI, Sonsoles; GONZALES CANTALAPIEDRA, Esther; HERNANDEZ HIGUERAS, Ana Isabel; VARELA BUSTO, Carmen; WO2011/36461; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem