Related Products of 27825-21-4, The chemical industry reduces the impact on the environment during synthesis 27825-21-4, name is Methyl 3-chloropyrazine-2-carboxylate, I believe this compound will play a more active role in future production and life.
The mixture of 1.35 g (7.8 mmol, 1 eq.) of 3-chloro-2-pyrazine methyl carboxylate prepared in example 20a), 0.7 ml (7.8 mmol, 1 eq.) of methyl thioglycolate and 1.62 g (11.7 mmol, 1.5 eq.) of K2CO3 in 60 ml of acetonitrile is heated under stirring for 16 hrs. The solvent is concentrated and immersed in 200 ml of water. After acidifying with 1N HCl, extraction is performed 3 times with CH2Cl2, the organic phase is dried on Na2CO3, filtered and evaporated. 1.21 g (73.5%) of aromatized product is obtained. FP=188 C. NMR (1H, DMSO): 2.50 (s; 3H; SCH3), 3.87 (s; OCH3), 8.81 (d, J=2.3 Hz; 1H, arom. H), 8.86 (d, J=2.3 Hz; 1H; arom. H), 11.67 (m; 1H; OH).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-chloropyrazine-2-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Imbert, Thierry; Monse, Barbara; Koek, Wouter; US2005/80085; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem