Some common heterocyclic compound, 117719-17-2, name is 5-Bromo-3-morpholinopyrazin-2-amine, molecular formula is C8H11BrN4O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 5-Bromo-3-morpholinopyrazin-2-amine
To a solution of Intermediate 1-02 (150 mg, 0.58 mmol) in Toluene (6.8 mE), 2-chloro-1,1-dimethoxypropane (0.758mE, 5.8 mmol) and p-toluenesulfonic acid (18 mg, 0.09 mmol) were added. The reaction mixture was refluxed for 24 hand additional amounts of 2-chloro-1 , 1-dimethoxypropane (10 eq) and p-toluenesulfonic acid (0.16 eq) were added. The reaction mixture was refluxed for 15 h and the solvent was removed. The residue was purified by column chromatography (Isolute 10 g; AcOEt-cyclohexane 0:100 to 50:50) to give the Intermediate 1-70 (55 mg, 32%) as a beige solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 117719-17-2, its application will become more common.
Reference:
Patent; CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO); Serrano Marugan, Manuel; Pastor Fernandez, Joaquin; Martinez Gonzalez, Sonia; Ortega Molina, Ana; Bischoff, James R.; Oyarzabal Santamarina, Julen; (220 pag.)US9993554; (2018); B2;,
Pyrazine – Wikipedia,
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