In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 113305-94-5 as follows. category: Pyrazines
2-Amino-5-cyano pyrazine (0.25 g, 2.08 mmol) was dissolved in a mixture of 3:1 THF and DCM (40 mL) and pyridine (0.49 g, 6.2 mmol) was added. The mixture was stirred for 15 minutes then phenylchloroformate (0.97 g, 6.2 mmol) was added and the reaction mixture was heated at 50 C. for 2 hours. The reaction mixture was allowed to cool to room temperature then DCM (40 mL) and water (25 mL) were added. The separated organic layer was washed with water (2*25 mL), brine (25 mL), dried (Na2SO4) and the solvents removed under reduced pressure to give the title compound (0.8 g) which was used without further purification.
According to the analysis of related databases, 113305-94-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Boyle, Robert George; Boyce, Richard Justin; US2014/323484; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem