Electric Literature of 274-79-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 274-79-3, name is Imidazo[1,2-a]pyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
lmidazo[1 ,2-a]pyrazine (1.191 g, 10 mmol, Intermediate 1 ) and sodium acetate (0.984 g, 12.00 mmol) were suspended in methanol (10 ml) saturated with potassium bromide (excess) and cooled to -10 0C. Bromine (0.515 ml_, 10.00 mmol) was added dropwise and the mixture stirred at -10 0C for 10 min. The solution was quenched by the addition of 1 N sodium sulfite solution (10 ml) and concentrated in vacuo. The residue was partitioned between ethyl acetate (100 ml) and 50% saturated sodium bicarbonate solution (100 ml). The aqueous phase was extracted with ethyl acetate (2 x 100 ml), combined, washed with brine (50 ml), dried over anhydrous sodium sulfate and concentrated to give crude 3-bromoimidazo[1 ,2-a]pyrazine (1.66 g, 8.38 mmol, 84 % yield) that was used in subsequent steps without further purification 3- bromoimidazo[1 ,2-a]pyrazine (1.66 g, 8.38 mmol, 84 % yield). LC/MS [M+H]+ = 198, 200, retention time = 0.53 minutes (2 minute method). 1H NMR (CDCI3, 400 MHz) d 9.09 (s, 1 H), 8.08 (s 1 H), 7.94 (s, 1 H), 7.81 (s, 1 H).
The synthetic route of Imidazo[1,2-a]pyrazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXO GROUP LIMITED; DEAN, David Kenneth; MUNOZ-MURIEDAS, Jorge; SIME, Mairi; STEADMAN, Jon Graham Anthony; THEWLIS, Rachel Elizabeth Anne; TRANI, Giancarlo; WALL, Ian David; WALTER, Daryl Simon; WO2010/125101; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem