Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6966-01-4, name is Methyl 3-amino-6-bromopyrazine-2-carboxylate, A new synthetic method of this compound is introduced below., name: Methyl 3-amino-6-bromopyrazine-2-carboxylate
Methyl 3-AMINO-6-BROMO-2-PYRAZINE-CARBOXYLATE (14.3 g9 61.6 mmol; see Example 16 (a) above) was suspended in 40 % aqueous METHYLAMINE (350 mL) and the resulting mixture was stirred vigorously for 7 hours at room temperature. The precipitate was collected, washed with water, and dried to afford 3-amino-6-bromo- pyrazine-2-carboxylic acid methylamide as a yellow solid (12.7 g, 90 %). H NMR (300 MHz, DMSO-D6) S2. 77 (d, J= 3 Hz, 3 H), 7.70 (br s, 2 H), 8. 33 (s, 1 H), 8. 56 (q, J= 3 Hz, 1 H); 13C NMR (100 MHz, DMSO-d6) #27.84, 123.49, 127.69, 150.43, 156.04, 167.18.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; BIOGEN IDEC MA INC.; WO2004/92177; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem