Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 109838-85-9, name is (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine, A new synthetic method of this compound is introduced below., SDS of cas: 109838-85-9
To (R)-2,5-dihydro-3,6-dimethoxy-2-isopropylpyrazine (2 mL, 11.03 mmol) in THF (90 mL) at -78 °C was added n-BuLi (1.6 M in hexanes solution, 7.5 mL, 12 mmol). After stirring for 30 min, l-bromo-3-(bromomethyl)-5-fluorobenzene (2.68 g, 10 mmol) in THF (10 mL) was added dropwise over 30 min. The temperature was maintained at -78 °C for 30 min then allowed to warm to ambient temperature. After stirring for 16 h, saturated aqueous NH4C1 (30 mL) was added followed by dilution with EtOAc and H20. The THF was removed in vacuo and the remaining organics were separated and dried over sodium sulfate. After removal of solvent, thecrude product was purified by silica gel chromatography to provide (2S,5R)-2-(3-bromo-5- fluorobenzyl)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine (3.17 g, 77percent). MS (m/z) 371 [M+H]+
The synthetic route of 109838-85-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GILEAD SCIENCES, INC.; BONDY, Steven, S.; CANNIZZARO, Carina, E.; CHOU, Chien-Hung; HU, Yunfeng, Eric; LINK, John, O.; LIU, Qi; SCHROEDER, Scott, D.; TSE, Winston, C.; ZHANG, Jennifer, R.; WO2014/110296; (2014); A1;,
Pyrazine – Wikipedia,
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