Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 762240-92-6, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride, A new synthetic method of this compound is introduced below., Recommanded Product: 762240-92-6
A round bottom flask is charged with 2,4,5-thfluorophenylacetic acid (25 g),Meldrums acid (20.5 g), N,N-dimethylaminopyhdine (1.28 g), and acetonitrile (75 ml_). Diisopropylethylamine (47.28 ml_) is added drop-wise, while maintaining the temperature below 500C. The mixture is heated to 500C, followed by drop-wise addition of pivalolyl chloride (17.8 ml_) over about 45 minutes. The mixture is maintained at the same temperature with stirring for 3 hours, followed by addition of thazole hydrochloride (30 g) in one portion. Subsequently, thfluoroacetic acid (2.95 ml_) is added and the mixture is maintained at 55C for another 6 hours. The mixture is cooled to room temperature, followed by distillation to remove acetonitrile and afford a residue. Water (100 ml_) and ethyl acetate (500 ml_) are added to the residue, and the organic layer is separated. The organic layer is washed with 5% sodium bicarbonate, then brine solution (50 ml_), and is dried over sodium sulphate, followed by distillation at 400C to form a ketoamide, i.e., 4- oxo-4-[3-(thfluoromethyl)-5,6-dihydro[1 ,2,4]thazolo[4,3a]pyrazin-7(8H)-yl]-1 -(2,4,5- trifluorophenyl)butan-2-one. lsopropyl alcohol (75 ml_) and (R)-(+)-1 – phenylethylamine (18.64 ml_) are added and the mixture is heated to 45-50C for 4 hours. The isopropyl alcohol is distilled completely below 40C to form a residue. Dichloromethane (200 ml_) and water (100 ml_) are mixed with the residue, followed by separation of the organic layer. The aqueous layer is extracted with dichloromethane (200 ml_). The organic layers are combined, washed with brine, dried over sodium sulphate, and distilled to afford a residue, which, on purification results in the title compound (28.7g, 42.8% yield).
The synthetic route of 762240-92-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; DR. REDDY’S LABORATORIES LTD.; DR. REDDY’S LABORATORIES, INC.; BANDICHHOR, Rakeshwar; GUDIMALLA, Nagaraju; DWIVEDI, Namrata; CHETLURU, Kiran Kumar; GADE, Srinivas Reddy; MUVVA, Venkateswarlu; SRIVASTAVA, Bindu; WO2011/25932; (2011); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem