Reference of 486424-37-7, These common heterocyclic compound, 486424-37-7, name is 3-Amino-6-bromopyrazine-2-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
3-Amino-6-bromo -N- (3,4- difluorobenzyl) pyrazine-2-carboxamide: A mixture of 1.51 g 3-amino-6-bromo-2-carboxylic acid (6.93 mM mole), 30 ml dimethylformamide, 1.23 ml 3,4-difluoro benzylamine (10.4 mmol) and 2.40 ml N, N- diisopropylethylamine (13.8 mmol) in combination and stirred together, the batch and then 2.89 g (7-azo BTA) -N, N, N ‘, N’- tetramethyluronium hexafluorophosphate (7.60 mmol) and stirred for two hours , was added 250 ml of ethyl acetate and 150 ml of water, filtered, the organic phase was washed with 150 ml aqueous sodium bicarbonate wash, 50 ml brine, dried over magnesium sulfate drained, purified by flash column chromatography (0-50 % ethyl acetate; n-hexane), to collect 0.899 g of yellow powder (38%).
The synthetic route of 486424-37-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BIOGEN MA INC.; SUNESIS PHARMACEUTICALS, INC.; ARNDT, JOSEPH; CHAN, TIMOTHY; GUCKIAN, KEVIN; KUMARAVEL, GNANASAMBANDAM; LEE, WEN-CHERNG; LIN, EDWARD YIN-SHIANG; SCOTT, DANIEL; SUN, LIHONG; THOMAS, JERMAINE; VAN VLOTEN, KURT; WANG, DEPING; ZHANG, LEI; ERLANSON, DANIEL; (469 pag.)TWI525093; (2016); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem