Adding a certain compound to certain chemical reactions, such as: 36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 36070-80-1, Application In Synthesis of 5-Chloropyrazine-2-carboxylic acid
To a cooled solution of 26 (3 g, 18.92 mmol, 1.0 eq), in N,N-dimethylformamide (30 mE) was added 1-[l3is (dimethylamino)methylene] -1 H-i ,2,3-triazolo[4,5-b]pyri- dinium 3-oxid hexafluorophosphate (8.65 g, 22.70 mmol, 1 .2 eq) and stirred at room temperature for 20 mm. Reaction mixture again cooled diisopropylethylamine (7.32 mE, 56.76 mmol, 3.0 eq) was added followed by addition of dimethylamine (0.851 g, 18.92 mmol, 1.0 eq). The reaction mixture was stirred at room temperature for 2 h. After completion of reaction, reaction mixture was transferred into water and product was extracted with ethyl acetate. Organic layer was combined, washed with brine solution, dried over sodium sulphate and concentrated under reduced pressure to obtain crude material. This was thrther purified by column chromatography and the compound was eluted in 0.9% methanol in dichioromethane to obtain 26.1(2.5 g, 71.18%). MS(ES): mlz 186.61 [M+H].
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Reference:
Patent; Nimbus Lakshmi, Inc.; Masse, Craig E.; Greenwood, Jeremy Robert; Mondal, Sayan; Cowen, Scott D.; McLean, Thomas H.; (624 pag.)US2019/31664; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem