Synthetic Route of 27398-39-6, The chemical industry reduces the impact on the environment during synthesis 27398-39-6, name is 3-Chloropyrazine-2-carboxylic acid, I believe this compound will play a more active role in future production and life.
General procedure: A total of 0.3 g of 3-Cl-POA (1.9 mmol) was dispersed in dry toluene with thionyl chloride(0.4 mL, 5.7 mmol, 3 equiv.) and 1?2 drops of N,N-dimethylformamide (DMF) as a catalyst. Thereaction mixture was stirred and heated in a round bottom flask in an oil bath under a condenser,at 95°C for 1 h. The solvent was evaporated in vacuo and the residue was azeotroped with dry toluene(3 20 mL). The acyl chloride was used for the following step, without purification. The whole amount of the 3-chloropyrazine-2-carbonyl chloride prepared in the previousstep was dissolved in dry acetone. An appropriate benzylamine (5.7 mmol, 3 equiv., with respect to the starting acid), along with triethylamine (1.9 mmol, 1 equiv.), were added to thereaction mixture and stirred at laboratory temperature overnight. The progress of the reactionwas checked by TLC in system hexane/ethyl acetate (1:1 or 2:1). The reaction mixture wasadsorbed to silica by removing the solvents in vacuo and the product was purified by flashchromatography using gradient elution with ethyl acetate in hexane. For compounds 1?3,corresponding N-benzyl-3-(benzylamino)pyrazine-2-carboxamides 1a?3a were formed simultaneouslyin a molar ratio of approximately 2:3, with an excess of 1a?3a. Rf in hexane/ethyl acetate 1:1 mobilephase: 1a?0.85, 1?0.49, 2a?0.84, 2?0.51, 3a?0.71, and 3?0.40. After flash-chromatography,compounds 2, 2a, 3, 3a, 4, 8, and 13 were recrystallized from EtOH/H2O.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Chloropyrazine-2-carboxylic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Semelkova, Lucia; Jand’ourek, Ond?ej; Kone?na, Klara; Paterova, Pavla; Navratilova, Lucie; Trejtnar, Franti?ek; Kubi?ek, Vladimir; Kune?, Ji?i; Dole?al, Martin; Zitko, Jan; McPhee, Derek J.; Molecules; vol. 22; 3; (2017);,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem